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Hemodynamic management of acute kidney injury.
Curr Opin Crit Care
December 2024
Department of Anesthesiology, Intensive Care & Perioperative Medicine, Assistance Publique Hôpitaux de Paris. Paris Saclay University, Paris, France.
Purpose Of Review: To discuss the role of hemodynamic management in critically ill patients with acute kidney injury.
Recent Findings: Acute kidney injury (AKI) may be associated with persistent alterations in renal perfusion, even when cardiac output and blood pressure are preserved. The effects of interventions aiming at increasing renal perfusion are best evaluated by renal Doppler or contrast enhance ultrasound.
Po-Ge-Jiu-Xin decoction alleviate sepsis-induced cardiomyopathy via regulating phosphatase and tensin homolog-induced putative kinase 1 /parkin-mediated mitophagy.
J Ethnopharmacol
January 2025
Department of Cardiology, The First Hospital of Lanzhou University, Key Laboratory of Cardiovascular Diseases of Gansu Province, Lanzhou, 730000, China. Electronic address:
Ethnopharmacological Relevance: Sepsis is a life-threatening systemic syndrome usually accompanied by myocardial dysfunction. Po-Ge-Jiu-Xin decoction (PGJXD), a traditional Chinese prescription medicine, has been used clinically to treat cardiovascular disease including heart failure, sepsis-induced cardiomyopathy (SIC) and even septic shock. Previous clinical studies suggested PGJXD has shown promising results in improving cardiac function and treating heart failure in sepsis.
View Article and Find Full Text PDFLevosimendan's Effects on Length-Dependent Activation in Murine Fast-Twitch Skeletal Muscle.
Int J Mol Sci
June 2024
Institute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-Nürnberg, Paul-Gordan Str. 3, 91052 Erlangen, Germany.
Levosimendan's calcium sensitizing effects in heart muscle cells are well established; yet, its potential impact on skeletal muscle cells has not been evidently determined. Despite controversial results, levosimendan is still expected to interact with skeletal muscle through off-target sites (further than troponin C). Adding to this debate, we investigated levosimendan's acute impact on fast-twitch skeletal muscle biomechanics in a length-dependent activation study by submersing single muscle fibres in a levosimendan-supplemented solution.
View Article and Find Full Text PDFSafety and efficacy of levosimendan in patients with cardiac amyloidosis.
Int J Cardiol
June 2024
Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Background: Patients with cardiac amyloidosis (CA) often experience heart failure (HF) episodes. No evidence is available on inotropic therapy. This study aims to fill this gap by examining the safety and efficacy of levosimendan.
View Article and Find Full Text PDFResponse to levosimendan predicts response to cardiac contractility modulation therapy: a pilot study.
Rev Esp Cardiol (Engl Ed)
August 2024
Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, Naples, Italy.
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