AI Article Synopsis
- Long-term memories related to drug use, such as heroin use disorder (HUD), are challenging to treat and can re-stabilize when exposed to drug-related cues.
- Histone acetylation plays a role in forming and reconsolidating these addictive memories, but the specific contribution of histone acetyltransferases (HAT) was previously unclear.
- In a rat model of self-administration, the HAT inhibitor garcinol was found to reduce the relapse of heroin-seeking behavior triggered by cues, suggesting its potential as a treatment for preventing relapse.
Article Abstract
Drug-associated long-term memories underlie substance use disorders, including heroin use disorder (HUD), which are difficult to eliminate through existing therapies. Addictive memories may become unstable when reexposed to drug-related cues and need to be stabilized again through protein resynthesis. Studies have shown the involvement of histone acetylation in the formation and reconsolidation of long-term drug-associated memory. However, it remains unknown whether and how histone acetyltransferases (HAT), the essential regulators of histone acetylation, contribute to the reconsolidation of heroin-associated memories. Herein, we investigated the function of HAT in the reconsolidation concerning heroin-conditioned memory by using a rat self-administration model. Systemic administration of the HAT inhibitor garcinol inhibited cue and heroin-priming induced reinstatement of heroin seeking, indicating the treatment potential of garcinol for relapse prevention.
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| http://dx.doi.org/10.1016/j.biopha.2024.116414 | DOI Listing |
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