Understanding the mechanisms underlying the generation and maintenance of leukemia stem cells (LSCs) is crucial for the development of effective therapies against T cell acute lymphoblastic leukemia (T-ALL). In a recent study, Rivera et al. discovered that elevated adenosine deaminase acting on RNA (ADAR)-1-mediated RNA editing is a distinguishing feature of T-ALL relapse, and that ADAR1 suppresses apoptosis triggered by the double-stranded (ds)RNA-sensing pathway.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047023 | PMC |
| http://dx.doi.org/10.1016/j.trecan.2024.02.005 | DOI Listing |
Publication Analysis
Top Keywords
leukemia stem
8
stem cells
8
limited dsrna
4
dsrna editing
4
editing impedes
4
impedes leukemia
4
cells understanding
4
understanding mechanisms
4
mechanisms underlying
4
underlying generation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!