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Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution.
Cell
January 2025
State Key Laboratory of Female Fertility Promotion, Department of Medical Genetics, School of Basic Medical Sciences, Peking University, Beijing 100191, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address:
During early mammalian development, the endoderm germ layer forms the foundation of the respiratory and digestive systems through complex patterning. This intricate process, guided by a series of cell fate decisions, remains only partially understood. Our study introduces innovative genetic tracing codes for 14 distinct endodermal regions using novel mouse strains.
View Article and Find Full Text PDFOpposite outcomes of triglyceride-glucose index and associated cardiovascular mortality risk in type 2 diabetes mellitus participants by different obesity criteria.
Sci Rep
January 2025
Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
We investigated the correlation between Triglyceride-glucose (TyG) index and cardiovascular disease (CVD) mortality in type 2 diabetes mellitus (T2DM) population across different obesity classications using a cohort study. We analyzed 7867 T2DM participants from the National Health and Nutrition Examination Survey 1999-2018, categorizing them into obese or non-obese group by body mass index (BMI) and waist circumference (WC). Cox regression models were used to estimate the correlation between TyG index and CVD mortality risk, comparing the results across the two obesity classifications.
View Article and Find Full Text PDFDeveloping and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design.
JMIR Cancer
January 2025
Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, United States.
Background: National guidelines recommend germline genetic testing (GT) for all patients with early-onset colorectal cancer. With recent advances in targeted therapies and GT, these guidelines are expected to expand to include broader groups of patients with colorectal cancer. However, there is a shortage of genetic professionals to provide the necessary education and support for informed consent.
View Article and Find Full Text PDFRe-evaluation and revision of the Eating Habits Questionnaire.
Psychiatr Hung
January 2025
Semmelweis University, Faculty of Medicine, Institute of Behavioural Sciences, Budapest, Hungary, E-mail:
Introduction: The Eating Habits Questionnaire (EHQ) is a key tool in evaluating orthorexia nervosa, an obsession with healthy eating. However, the evaluation process of EHQ has witnessed considerable variation, with one item notably excluded from the last phase of its development. This study undertakes a thorough re-evaluation of the English version of the EHQ, focusing on its original 35 items, within two diverse populations (fashion models and university students) where English serves predominantly as a second language.
View Article and Find Full Text PDFImpact of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal outcomes: a pilot randomised clinical trial.
BMJ Open
December 2024
Department of Anesthesiology, Peking University First Hospital, Beijing, China
Objective: To investigate the impact of dexmedetomidine-ropivacaine combination versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal and maternal outcomes and test the feasibility of a future large, randomised trial.
Design: A randomised, double-blind, pilot clinical trial from 16 March 2023 to 15 June 2023.
Setting: A tertiary-care hospital in Beijing, China.
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