The mSWI/SNF subunits ARID1A and SMARCA4 are mutated in B cell lymphomas. Now, Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to lymphomagenesis by causing B cells to aberrantly re-enter germinal centers where they undergo repeated rounds of proliferation and somatic hypermutation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318343 | PMC |
| http://dx.doi.org/10.1016/j.ccell.2024.02.006 | DOI Listing |
Publication Analysis
Top Keywords
arid1a smarca4
8
swi/snf regulation
4
regulation germinal
4
germinal center
4
center fate
4
fate lymphomagenesis
4
lymphomagenesis mswi/snf
4
mswi/snf subunits
4
subunits arid1a
4
smarca4 mutated
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!