AI Article Synopsis
- Two pediatric patients with Crohn's disease experienced kidney injury linked to ADM therapy; one showed irreversible damage despite treatment, while the other's kidney function improved after stopping the drug.
- Monitoring kidney function and consulting specialists are crucial for patients on ADM, as timely discontinuation can prevent further damage but may not reverse existing harm.
Article Abstract
Introduction: Adalimumab (ADM) is a recombinant human monoclonal antibody (anti-TNFα) used to treat inflammatory bowel diseases. It can cause kidney injury (KI).
Case Diagnosis/treatment: We describe two pediatric patients with Crohn's disease (CD) in whom ADM therapy was associated with kidney injury (KI). The drug was discontinued in both cases. For the first patient, changes were irreversible despite intensive glucocorticosteroid (GCS) therapy. For the second patient, discontinuation of ADM led to an improvement in kidney function.
Conclusions: Due to the risk of KI in patients undergoing ADM therapy, careful assessment of kidney function and early specialist referral are required. Timely withdrawal of ADM can significantly reduce kidney damage, but in some cases, the kidney damage can be irreversible.
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| http://dx.doi.org/10.1007/s00467-024-06338-0 | DOI Listing |
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