Ether C-O bonds are typical constituents of organic molecules that are seldom regarded as reactive functional groups except when highly strained. With the assistance of appropriate directing groups, low-valent titanium was found to homolytically cleave non-strained C-O bonds. In particular, a newly designed catechol monoether directing group rendered a route toward the activation of non-benzylic C(sp)-O bonds. This method has been applied to conventional radical addition reactions to alkenes.
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| http://dx.doi.org/10.1021/acs.orglett.4c00590 | DOI Listing |
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