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Revolutionizing breast cancer treatment: Harnessing the related mechanisms and drugs for regulated cell death (Review). | LitMetric

Revolutionizing breast cancer treatment: Harnessing the related mechanisms and drugs for regulated cell death (Review).

Int J Oncol

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830017, P.R. China.

Published: May 2024

AI Article Synopsis

  • - Breast cancer develops from the harmful transformation of mammary cells influenced by various factors, making it the leading cause of cancer-related deaths in women due to diagnostic challenges and often late-stage discovery.
  • - Traditional treatments like surgery, chemotherapy, and radiotherapy are often not very effective against breast cancer's progression, leading researchers to explore regulated cell death (RCD) mechanisms, particularly focusing on cuproptosis, ferroptosis, and pyroptosis.
  • - Recent studies indicate that these RCD mechanisms can impact breast cancer cell behavior and treatment responses, suggesting they could lead to new strategies for enhancing chemotherapy effectiveness and improving patient outcomes.

Article Abstract

Breast cancer arises from the malignant transformation of mammary epithelial cells under the influence of various carcinogenic factors, leading to a gradual increase in its prevalence. This disease has become the leading cause of mortality among female malignancies, posing a significant threat to the health of women. The timely identification of breast cancer remains challenging, often resulting in diagnosis at the advanced stages of the disease. Conventional therapeutic approaches, such as surgical excision, chemotherapy and radiotherapy, exhibit limited efficacy in controlling the progression and metastasis of the disease. Regulated cell death (RCD), a process essential for physiological tissue cell renewal, occurs within the body independently of external influences. In the context of cancer, research on RCD primarily focuses on cuproptosis, ferroptosis and pyroptosis. Mounting evidence suggests a marked association between these specific forms of RCD, and the onset and progression of breast cancer. For example, a cuproptosis vector can effectively bind copper ions to induce cuproptosis in breast cancer cells, thereby hindering their proliferation. Additionally, the expression of ferroptosis‑related genes can enhance the sensitivity of breast cancer cells to chemotherapy. Likewise, pyroptosis‑related proteins not only participate in pyroptosis, but also regulate the tumor microenvironment, ultimately leading to the death of breast cancer cells. The present review discusses the unique regulatory mechanisms of cuproptosis, ferroptosis and pyroptosis in breast cancer, and the mechanisms through which they are affected by conventional cancer drugs. Furthermore, it provides a comprehensive overview of the significance of these forms of RCD in modulating the efficacy of chemotherapy and highlights their shared characteristics. This knowledge may provide novel avenues for both clinical interventions and fundamental research in the context of breast cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11000534PMC
http://dx.doi.org/10.3892/ijo.2024.5634DOI Listing

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