AI Article Synopsis
- The research focused on creating new chloroquine analogues to test their effectiveness against microbes and cancer cells.
- The synthesized analogues were found to have significant antimicrobial properties, with one analogue showing a 30.3 mm zone of inhibition against a specific microbe.
- Additionally, one analogue demonstrated strong cytotoxic effects on HeLa cells, achieving 100% cell inhibition at a low concentration, outperforming the original chloroquine.
Article Abstract
To synthesize novel chloroquine analogues and evaluate them for antimicrobial and cytotoxic potential. Novel analogues were synthesized from chloroquine by nucleophilic substitution reaction at the 4-amino position. Analogue showed maximum antimicrobial potential (30.3 ± 0.15 mm zone) against and produced a 19.2 ± 0.21 mm zone against , while produced no zone at the same concentration. Analogue has excellent cytotoxic potential (HeLa cell line), showing 100% inhibition (IC = 8.9 ± 1.2 μg/ml), compared with (61.9% inhibition at 30 μg/ml). These synthesized chloroquine analogues have excellent activity against different microbial strains and cervical cancer cell lines (HeLa) compared with their parent molecule.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221543 | PMC |
| http://dx.doi.org/10.4155/fmc-2023-0343 | DOI Listing |
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