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Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? | LitMetric

AI Article Synopsis

  • HIV, once a death sentence, is now manageable with antiretroviral therapy (ART), which effectively halts AIDS progression and makes the virus untransmissible for many with undetectable viral loads.
  • Though ART significantly improves the life expectancy of people living with HIV (PLWH), it cannot eliminate the latent reservoir of the virus in infected cells.
  • Despite progress in reducing new infections and increased ART accessibility, researchers are still struggling to find a definitive cure for HIV, exploring various strategies to eradicate or control the virus long-term.

Article Abstract

Once a death sentence, HIV is now considered a manageable chronic disease due to the development of antiretroviral therapy (ART) regimens with minimal toxicity and a high barrier for genetic resistance. While highly effective in arresting AIDS progression and rendering the virus untransmissible in people living with HIV (PLWH) with undetectable viremia (U=U) [1, 2]), ART alone is incapable of eradicating the "reservoir" of resting, latently infected CD4 T cells from which virus recrudesces upon treatment cessation. As of 2022 estimates, there are 39 million PLWH, of whom 86% are aware of their status and 76% are receiving ART [3]. As of 2017, ART-treated PLWH exhibit near normalized life expectancies without adjustment for socioeconomic differences [4]. Furthermore, there is a global deceleration in the rate of new infections [3] driven by expanded access to pre-exposure prophylaxis (PrEP), HIV testing in vulnerable populations, and by ART treatment [5]. Therefore, despite outstanding issues pertaining to cost and access in developing countries, there is strong enthusiasm that aggressive testing, treatment, and effective viral suppression may be able to halt the ongoing HIV epidemic (ie, UNAIDS' 95-95-95 targets) [6-8]; especially as evidenced by recent encouraging observations in Sydney [9]. Despite these promising efforts to limit further viral transmission, for PLWH, a "cure" remains elusive; whether it be to completely eradicate the viral reservoir (ie, cure) or to induce long-term viral remission in the absence of ART (ie, control; Figure 1). In a previous salon hosted by in 2016 [10], some researchers were optimistic that a cure was a feasible, scalable goal, albeit with no clear consensus on the best route. So, how are these cure strategies panning out? In this commentary, 8 years later, we will provide a brief overview on recent advances and failures towards identifying determinants of viral persistence and developing a scalable cure for HIV. Based on these observations, and as in the earlier salon, we have asked several prominent HIV cure researchers for their perspectives.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919397PMC
http://dx.doi.org/10.20411/pai.v8i2.665DOI Listing

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