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Dynamic molecular architecture of the synaptonemal complex.
Sci Adv
January 2025
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.
During meiosis, pairing between homologous chromosomes is stabilized by the assembly of the synaptonemal complex (SC). The SC ensures the formation of crossovers between homologous chromosomes and regulates their distribution. However, how the SC regulates crossover formation remains elusive.
View Article and Find Full Text PDFClinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration.
JAMA Cardiol
January 2025
National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, United Kingdom.
Importance: Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages with no heart failure (HF) symptoms and a wide range of cardiac amyloid infiltration.
Objective: To characterize the clinical phenotype and natural history of asymptomatic patients with ATTR cardiac amyloid infiltration.
Design, Setting, And Participants: This cohort study analyzed data of all patients at 12 international centers for amyloidosis from January 1, 2008, through December 31, 2023.
Factors Relating to Sprint Swimming Performance: A Systematic Review.
Sports Med
January 2025
Aquatics Lab, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Background: Swimming performance depends on a wide variety of factors; however, the interaction between these factors and their importance varies between events. In sprint events, the characterized pacing underlines its specific development, as swimmers must achieve the highest possible speed while sustaining it to the greatest extent possible.
Objectives: The aim of this review was to identify the key factors underlying sprint swimming performance and to provide in-depth and practical evidence-based information to optimize performance.
Adaptive evolutionary trajectories in complexity: Transitions between unicellularity and facultative differentiated multicellularity.
Proc Natl Acad Sci U S A
January 2025
Department of Mathematics and Mathematical Statistics, Umeå University, Umeå 90187, Sweden.
Multicellularity spans a wide gamut in terms of complexity, from simple clonal clusters of cells to large-scale organisms composed of differentiated cells and tissues. While recent experiments have demonstrated that simple forms of multicellularity can readily evolve in response to different selective pressures, it is unknown if continued exposure to those same selective pressures will result in the evolution of increased multicellular complexity. We use mathematical models to consider the adaptive trajectories of unicellular organisms exposed to periodic bouts of abiotic stress, such as drought or antibiotics.
View Article and Find Full Text PDFFacile Fabrication of Multifunctional Superhydrophobic Surfaces Synthesized by the Additive Manufacturing Technique Modified with ZnO Nanoparticles.
Langmuir
January 2025
Department of Physics, SRM University AP Andhra Pradesh, Mangalagiri, Andhra Pradesh 522502, India.
This article reports facile fabrication of a multifunctional smart surface having superhydrophobic self-cleaning property, superoleophilicity, and antimicrobial property. These smart surfaces have been synthesized using the stereolithography (SLA) method of the additive manufacturing technique. SLA is a fast additive manufacturing technique used to create complex parts with intricate geometries.
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