AI Article Synopsis
- Seven new compounds, along with six known ones, were extracted from Aspergillus quadrilineatus, and their structures were determined using advanced techniques like NMR and ECD calculations.
- Quadrilisteroids A (1) and B (2) featured unique complex ring systems, while quadrilisteroid C (3) had an unusual fused carbocyclic skeleton.
- Quadrilisteroid C (3) showed strong anti-proliferative effects on B lymphocyte cells, and compound 4 inhibited T lymphocyte cell proliferation, showcasing the compounds' potential biological activities.
Article Abstract
Seven undescribed compounds (1-7) along with six known compounds (8-13) were isolated from Eurotiaceae Aspergillus quadrilineatus. Their structures and absolute configurations were elucidated by NMR, HRESIMS, and ECD calculations. Quadrilisteroids A (1) and B (2) possessed an unprecedented 6/5/6/6/6/5 hexacyclic ring system in conjugation with a highly fused benzene ring, while quadrilisteroid C (3) featured a surprising 6/6/6/5/5-fused carbocyclic skeleton. Quadrilisteroid C (3) exhibited potent inhibitory activity against LPS-induced proliferation of B lymphocyte cells with an IC value of 1.03 μM. Compound 4, demonstrated inhibitory activity against Con A-induced proliferation of T lymphocyte cells with IC values of 6.42 μM.
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| http://dx.doi.org/10.1016/j.phytochem.2024.114044 | DOI Listing |
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