The article by Lock et al. in this month's issue of the Journal highlights 3 features that are of interest to child and adolescent psychiatrists. First, it provides further evidence for an effective therapy for an extremely debilitating condition, with additional means for improving prognosis. Second, it underscores how families can be helpful in supporting therapy for their children, thus avoiding unnecessary scapegoating of parents. Finally, it is a fine example of a clinical trial performed in accordance with all the principles of modern methodology.
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| http://dx.doi.org/10.1016/j.jaac.2024.02.011 | DOI Listing |
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Raynaud Syndrome Associated with Medication for Attention-Deficit/Hyperactivity Disorder: A Systematic Review.
CNS Drugs
January 2025
Faculty of Environmental and Life Sciences, Centre for Innovation in Mental Health, School of Psychology, University of Southampton, Southampton, UK.
Background: Raynaud syndrome (RS) is a peripheral vasculopathy characterised be impaired acral perfusion typically manifesting as skin discolouration with pallor, cyanosis and/or erythema, and increased sensitivity to cold. RS may be primary or secondary to systemic disease, lifestyle and environmental factors or medication. RS has been reported with medication to treat ADHD, but we found no recent comprehensive overview of the literature.
View Article and Find Full Text PDFLung-targeted delivery of PTEN mRNA combined with anti-PD-1-mediated immunotherapy for In Situ lung cancer treatment.
Acta Biomater
January 2025
College of Chemistry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China. Electronic address:
mRNA-based protein replacement therapy has become one of the most widely applied forms of mRNA therapy, with lipid nanoparticles (LNPs) being extensively studied as efficient delivery platforms for mRNA. However, existing LNPs tend to accumulate in the liver or kidneys after intravenous injection, highlighting the need to develop vectors capable of targeting specific organs. In this study, we synthesized a small library of ionizable lipids and identified PPz-2R as a promising candidate, exhibiting lung-targeting capabilities, high mRNA transfection efficiency, and good stability through structure-activity relationship studies.
View Article and Find Full Text PDFLarge-Scale Validation of the Feasibility of GPT-4 as a Proofreading Tool for Head CT Reports.
Radiology
January 2025
From the Departments of Biomedical Systems Informatics (S.K., Jaewoong Kim, C.H., D.Y.) and Neurology (Joonho Kim, J.Y.), Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea; Department of Radiology, Central Draft Physical Examination Office of Military Manpower Administration, Daegu, Republic of Korea (D.K.); Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science (H.J.S. Y.K., S.J.), and Center for Digital Health (H.J.S., D.Y.), Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea; Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (S.H.L.); Departments of Radiology (M.H.) and Neurology (S.J.L.), Ajou University Hospital, Ajou University School of Medicine, Suwon, Republic of Korea; and Institute for Innovation in Digital Healthcare, Severance Hospital, Seoul, Republic of Korea (D.Y.).
Background The increasing workload of radiologists can lead to burnout and errors in radiology reports. Large language models, such as OpenAI's GPT-4, hold promise as error revision tools for radiology. Purpose To test the feasibility of GPT-4 use by determining its error detection, reasoning, and revision performance on head CT reports with varying error types and to validate its clinical utility by comparison with human readers.
View Article and Find Full Text PDFGlucose-6-phosphate dehydrogenase regulates mitophagy by maintaining PINK1 stability.
Life Metab
February 2025
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.
Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) in glycolysis. Glucose metabolism is closely implicated in the regulation of mitophagy, a selective form of autophagy for the degradation of damaged mitochondria. The PPP and its key enzymes such as G6PD possess important metabolic functions, including biosynthesis and maintenance of intracellular redox balance, while their implication in mitophagy is largely unknown.
View Article and Find Full Text PDFidentification through bronchoscope in intensive care unit - a retrospective, databased cohort study.
Front Cell Infect Microbiol
January 2025
Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Introduction: Invasive pulmonary aspergillosis (IPA) increases the risk of mortality of critically ill patients. Diagnostic criteria specifically targeting patients in intensive care units(ICUs) have been developed to improve diagnostic sensitivity. This study investigated health outcomes among patients in ICUs with Aspergillus isolates identified using bronchoscopy.
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