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B cells and tertiary lymphoid structures in tumors: immunity cycle, clinical impact, and therapeutic applications.
Theranostics
January 2025
Hepatic Surgery Center, and Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P. R. China.
Tumorigenesis involves a multifaceted and heterogeneous interplay characterized by perturbations in individual immune surveillance. Tumor-infiltrating lymphocytes, as orchestrators of adaptive immune responses, constitute the principal component of tumor immunity. Over the past decade, the functions of tumor-specific T cells have been extensively elucidated, whereas current understanding and research regarding intratumoral B cells remain inadequate and underexplored.
View Article and Find Full Text PDFSARS-CoV-2 strains and clinical profiles of COVID-19 patients in a Southern Brazil hospital.
Front Immunol
January 2025
Laboratory of Genomic Medicine, Center of Experimental Research, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
Introduction: The COVID-19 pandemic had a widespread global impact and presented numerous challenges. The emergence of SARS-CoV-2 variants has changed transmission rates and immune evasion, possibly impacting the severity. This study aims to investigate the impact of variants on clinical outcomes in southern Brazil.
View Article and Find Full Text PDFExpressional and prognostic value of TREM1 in ovarian cancer: A comprehensive study based on bioinformatics and clinical analysis validation.
J Cancer
January 2025
Department of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Triggering receptor expressed in myeloid cells-1 (TREM1) is an important regulator of innate and adaptive immunity, which can directly amplify an inflammatory response. Current studies have found the immunomodulatory role of TREM1 in tumor microenvironment. However, the role of TREM1 in ovarian cancer (OV) remains unclear.
View Article and Find Full Text PDFDNA methylation in wheat: current understanding and future potential for enhancing biotic and abiotic stress tolerance.
Physiol Mol Biol Plants
December 2024
Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215 India.
Unlabelled: DNA methylation is a paramount epigenetic mark that helps balance gene expression post-transcriptionally. Its effect on specific genes determines the plant's holistic development and acclimatization during adversities. L.
View Article and Find Full Text PDFtRNA-derived small RNAs in disease immunity.
Theranostics
January 2025
Department of Respiratory and Critical Care, Chengdu Third People's Hospital, Chengdu, China.
Recently, members of a unique species of non-coding RNA, known as transfer RNA-derived small RNAs (tsRNAs) have been reported to serve multiple molecular functions, including in cells that mediate immunity. Because of their low molecular weights, tsRNAs were previously difficult to detect and were thus overlooked, until now. In this review, we delve into the biogenesis of tsRNAs and their diverse biological functions, ranging from transcriptional regulation to modulation of mRNA translation.
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