AI Article Synopsis
- The study aimed to compare the transdermal delivery methods of Sinomenine hydrochloride using solid lipid nanoparticles, liposomes, and nanoemulsions.
- The researchers prepared each formulation using different methods and analyzed their properties, including particle size, encapsulation efficiency, and their impact on skin penetration.
- Results showed that solid lipid nanoparticles significantly altered the lipid structure of the outer skin layer, allowing for better permeation of the drug compared to the other methods.
Article Abstract
Objective: To investigate the transdermal mechanisms and compare the differences in transdermal delivery of Sinomenine hydrochloride (SN) between solid lipid nanoparticles (SLN), liposomes (LS), and nanoemulsions (NE).
Methods: SN-SLN, SN-LS and SN-NE were prepared by ultrasound, ethanol injection and spontaneous emulsification, respectively. FTIR, DSC, in vitro skin penetration, activation energy (Ea) analysis were used to explore the mechanism of drug penetration across the skin.
Results: The particle size and encapsulation efficiency were 126.60 nm, 43.23 ± 0.48%(w/w) for SN-SLN, 224.90 nm, 78.31 ± 0.75%(w/w) for SN-LS, and 83.22 nm, 89.01 ± 2.16%(w/w) for SN-LS. FTIR and DSC showed the preparations had various levels of impacts on the stratum corneum's lipid structure which was in the order of SLN > NE > LS. Ea values of SN-SLN, SN-LS, and SN-NE crossing the skin were 2.504, 1.161, and 2.510 kcal/mol, respectively.
Conclusion: SLN had a greater degree of alteration on the skin cuticle, which allows SN to permeate skin more effectively.
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| http://dx.doi.org/10.1080/02652048.2024.2324810 | DOI Listing |
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