AI Article Synopsis
- * Although monkeypox typically resolves on its own, it can cause very painful skin lesions and complications that may lead to death.
- * The similarities between the monkeypox and smallpox viruses allow for the use of smallpox vaccines in prevention, but more research is needed to understand the immune response to monkeypox.
Article Abstract
Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10914130 | PMC |
| http://dx.doi.org/10.52225/narra.v2i3.90 | DOI Listing |
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