Synergistic effect of extracts on skin aging regulation. From predictions to outcome.

Intrinsic and extrinsic aging affect the health of human skin. Extracellular matrix protein degradation, DNA damage and oxidative stress are known to disturb skin architecture and skin homeostasis leading to skin aging. Traditional Chinese Medicine (TCM) delivers a large amount of knowledge regarding the phytotherapeutic power of diverse plants. , , , and are five plants used in TCM for their protective effect. In this study, several combinations of these TCM plants were explored: first, an analysis was performed to predict their potential to target biological activities in the skin and then, some predictions were verified with studies to underline the synergistic effect of plant extracts. The results showed a stronger anti-aging activity for the combination with the five plants compared to the combination with , , and, compared to alone.