Skin cancer is a prevalent form of cancer that necessitates prompt and precise detection. However, current diagnostic methods for skin cancer are either invasive, time-consuming, or unreliable. Consequently, there is a demand for an innovative and efficient approach to diagnose skin cancer that utilizes non-invasive and automated techniques. In this study, a unique method has been proposed for diagnosing skin cancer by employing an Xception neural network that has been optimized using Boosted Dipper Throated Optimization (BDTO) algorithm. The Xception neural network is a deep learning model capable of extracting high-level features from skin dermoscopy images, while the BDTO algorithm is a bio-inspired optimization technique that can determine the optimal parameters and weights for the Xception neural network. To enhance the quality and diversity of the images, the ISIC dataset is utilized, a widely accepted benchmark system for skin cancer diagnosis, and various image preprocessing and data augmentation techniques were implemented. By comparing the method with several contemporary approaches, it has been demonstrated that the method outperforms others in detecting skin cancer. The method achieves an average precision of 94.936%, an average accuracy of 94.206%, and an average recall of 97.092% for skin cancer diagnosis, surpassing the performance of alternative methods. Additionally, the 5-fold ROC curve and error curve have been presented for the data validation to showcase the superiority and robustness of the method.
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http://dx.doi.org/10.1016/j.heliyon.2024.e26415 | DOI Listing |
J Med Case Rep
January 2025
Department of Dermatology and Venereology, Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Background: Basal cell nevus syndrome, also known as Gorlin or Gorlin-Goltz syndrome, is a hereditary condition caused by mutation in the PATCHED gene. The syndrome presents with a wide range of clinical manifestations, including basal cell carcinomas, jaw cysts, and skeletal anomalies. Diagnosis is based on specific criteria, and treatment typically includes surgical removal of basal cell carcinomas.
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January 2025
Division of Medical Oncology, Marmara University School of Medicine, Istanbul, Turkey.
Management of melanoma has changed significantly with the discovery of targeted therapies and immune checkpoint inhibitors (ICI). Our aim in the study is to determine which treatment alternatives, specifically dabrafenib plus trametinib and ICIs, are effective in adjuvant therapy and which treatment is effective as first-line metastatic therapy. This retrospective, multicenter study included 120 patients diagnosed with stage IIIB-IIID melanoma receiving both adjuvant and first-line metastatic treatment between 2007 and 2023.
View Article and Find Full Text PDFRadiother Oncol
January 2025
School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Radiation Unit, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel; GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands. Electronic address:
Unlabelled: Our previous study on BRCA breast cancer carriers disclosed a high local recurrence (LR) rate in patients who underwent skin sparing (SSM) or nipple sparing mastectomy (NSM) without postoperative radiation therapy (RT), compared to breast conservation surgery or mastectomy with RT. The current study compares the LR rates in BRCA versus non BRCA carriers after SSM/NSM in relation the receipt of RT.
Methods: The study was approved by the institutional ethics committee.
Burns
January 2025
Department of Dermatology, Hochgebirgsklinik, Davos, Switzerland. Electronic address:
Int J Surg Case Rep
January 2025
Department of Head and Neck Surgery, Institut de Cancérologie de Lorraine, 6 avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France; CRAN, CNRS, UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France; Faculté d'odontologie de Lorraine, Université de Lorraine, Vandœuvre-lès-Nancy, France.
Introduction: Large melanomas, while relatively uncommon, present significant diagnostic challenges due to their size and potential to mimic other malignancies, leading to delays in appropriate treatment. Initial misdiagnosis is a substantial concern, impacting patient outcomes. This case highlights the importance of immunohistochemistry in cancer diagnosis, and of appropriate therapeutic management, which here included excision surgery of the tumor mass.
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