Larvicidal Activity of Some Aromatic Thiosemicarbazone and Metal Complexes [Ni (II), Cu (II), Co (II)] Against (Linnaeus, 1762) and (Skuse, 1894) (Diptera: Culicidae) Larvae.

Objective: A series of aromatic thiosemicarbazone-oxime [TP1 and TP2] derivatives and their Ni(II), Cu(II), and Co(II) complexes were synthesized, and their larvicidal activity was evaluated against and larvae. The efficacy of these substances to larvae has been demonstrated for the first time.

Methods: Laboratory colonized and larvae were subjected to larvicidal activity tests. Larval mortality rates at 24 and 48 hours were recorded and LC values were calculated. The study was carried out at Aydın Adnan Menderes University in 2021.

Results: For , LC of TP1 and its Co(II) complex were 15.41, 9.75, μg/mL whereas for TP2 and its Co(II) complex, LC were 21.62, 20.50 μg/mL after 24 and 48 h respectively. For , TP1 and its Co(II) complex showed an LC of 12.06, 8.75 μg/mL, whereas TP2 and its Co(II) complex showed an LC of 32.87, 25.48 μg/mL, for 24, and 48 h respectively.

Conclusion: Both TP1 and TP2 compounds and their Co(II) complexes presented high efficacy against the larvae; it can be said that C=S groups in thiosemicarbazone derivatives are effective in showing activity and for this reason, studies should be continued to make these components effective.