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Achieving malaria-free: Egypt's journey to WHO certification and global implications for disease control.
Trop Med Health
December 2024
Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
Egypt's recent malaria-free certification by the World Health Organization (WHO) marks a significant achievement in public health, underscoring the effectiveness of sustained national efforts in disease eradication. This milestone, achieved after nearly a century of strategic intervention, highlights the importance of integrated public health programmes and cross-sector collaboration. Egypt's journey involved early initiatives to reduce human-mosquito contact, the establishment of malaria control stations, and comprehensive outbreak management strategies.
View Article and Find Full Text PDFImmunophenotypic analysis on circulating T cells for early diagnosis of lung cancer.
Biomark Res
December 2024
Department of Microbiology and Immunology, Chonnam National University Medical School, Hwasunup, Jeollanamdo, 58128, Republic of Korea.
The immune system continuously interacts with tumors, possibly leading to systemic alterations in circulating immune cells. However, the potential of these cancer-associated changes for diagnostic purposes remains poorly explored. To investigate this, we conducted a comprehensive flow cytometric analysis of 452 peripheral blood mononuclear cell (PBMC) samples from 206 non-small-cell lung cancer (NSCLC) patients, 100 small-cell lung cancer (SCLC) patients, 94 healthy individuals, and 52 benign lung disease (BLD) patients.
View Article and Find Full Text PDFResponse to "Screening for LifeThreatening Arrhythmia in Asymptomatic Patients After Paediatric Cardiac Surgery: A Single Centre Retrospective Analysis of 790 Prehospitaldischarge 24 h Holter Electrocardiogram Recordings".
Pediatr Cardiol
December 2024
Shaheed Mohtarma Benazir Bhutto Medical College, Lyari, Karachi, Pakistan.
To the editor! We read the study published in your journal with great enthusiasm and appreciate the authors' efforts to perform the research [1]. It sheds light on the discussed cause and aids comprehension of the topic at hand. For sure, it provides the groundwork for future research; nevertheless, we have a few doubts that have caused us to write this letter, and we are confident that if these doubts were addressed, the overall output of the study would have increased manifolds.
View Article and Find Full Text PDFDisease Modules Associated with Unfavorable Sleep Patterns and Their Genetic Determinants: A Prospective Cohort Study of the UK Biobank.
Phenomics
October 2024
Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, 610000 China.
Unlabelled: Despite the established associations between sleep-related traits and major diseases, comprehensive assessment on affected disease modules and their genetic determinants is lacking. Using multiple correspondence analysis and the k-means clustering algorithm, 235,826 eligible participants were clustered into distinct unfavorable sleep patterns [short sleep duration ( = 10,073), snoring (22,419), insomnia (102,771), insomnia and snoring (62,909)] and favorable sleep pattern groups (37,654). The associations of unfavorable sleep patterns with 134 diseases were estimated using Cox regression models; and comorbidity network analyses were applied for disease module identification.
View Article and Find Full Text PDFPhylogeny and divergence time estimation of the subfamily Amphipsyllinae based on the mitogenome.
Front Vet Sci
December 2024
Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Institute of Pathogens and Vectors, Dali University, Dali, China.
Fleas are primarily parasites of small mammals and serve as essential vectors of the transmission of plague. The subfamily Amphipsyllinae (Siphonaptera: Leptopsyllidae) consists of 182 species across 13 genera, widely distributed worldwide. Only two species of Amphipsyllinae have been sequenced for complete mitogenomes to date.
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