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The potential role of hydrogen sulfide in cancer cell apoptosis. | LitMetric

The potential role of hydrogen sulfide in cancer cell apoptosis.

Cell Death Discov

Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475004, China.

Published: March 2024

AI Article Synopsis

Article Abstract

For a long time, hydrogen sulfide (HS) has been considered a toxic compound, but recent studies have found that HS is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that HS mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways. Therefore, the regulation of the production and metabolism of HS to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment. In this review, the role and mechanism of HS in cancer cell apoptosis in mammals are summarized.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917771PMC
http://dx.doi.org/10.1038/s41420-024-01868-wDOI Listing

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