AI Article Synopsis
- Bispecific antibodies, like talquetamab, have improved treatment options for multiple myeloma by redirecting T cells to target specific cancer cells.
- Talquetamab targets GPRC5D, leading to skin toxicity, which poses challenges for patient management.
- A case study revealed that a patient experienced severe skin toxicity from talquetamab following a stem cell treatment, highlighting the need for personalized care in using novel immunotherapies alongside traditional treatments.
Article Abstract
Introduction: Bispecific antibodies have meaningfully expanded the therapeutic armamentarium in multiple myeloma. Talquetamab is a CD3+ T-cell-redirecting antibody targeting GPRC5D, which is expressed on multiple myeloma plasma cells as well as in keratinized tissues. Due to the expression pattern, toxicity of talquetamab involves skin toxicity.
Case Presentation: Here we report the case of a patient who was treated with talquetamab after relapse after CAR-T therapy. The patient developed a severe recurrence of talquetamab-mediated skin toxicity after the administration of a supportive hematopoietic stem cell boost to treat persistent late cytopenias after CAR-T therapy.
Conclusion: This case underscores the complex dynamics between novel immunotherapies like talquetamab and stem cell-based interventions in the context of MM treatment, shedding light on the need for personalized approaches to maximize the benefits of these therapies while minimizing their associated adverse effects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610452 | PMC |
| http://dx.doi.org/10.1159/000538047 | DOI Listing |
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