Sister Mary Joseph nodule (SMJN) is a rare clinical finding in patients with metastatic adenocarcinoma. This is a case report of a 69-year-old man, who presented with a cutaneous element by his umbilicus at his GP. He was referred to a dermatologist, then a plastic surgeon. The element was a metastasis from adenocarcinoma originating from his caecum. It is important for doctors to know of SMJN as a rare presentation of metastatic cancer, and to clinically examine the patient for an abdominal starting point, when presented with a cutaneous tumour at the position of the umbilicus.
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Sister Mary Joseph's Nodule as a Cutaneous Expression of Metastatic Pancreatic Adenocarcinoma.
Cureus
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Pathology, East Alabama Medical Center, Opelika, USA.
A Sister Mary Joseph's nodule (SMJN) is characterized by a palpable umbilical nodule and is often a clinical indicator of the metastasis of an advanced abdominal or pelvic malignancy. Observing the cutaneous manifestation of an abdomino-pelvic malignancy is a relatively rare phenomenon due to the appearance of visible changes in the later stages of the disease. With the pancreas being a less common primary tumor site for SMJN, this case report describes a 57-year-old male diagnosed with metastatic pancreatic adenocarcinoma with a SMJN.
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Ugeskr Laeger
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Plastikkirurgisk Afdeling, Københavns Universitetshospital - Herlev Hospital.
Sister Mary Joseph nodule (SMJN) is a rare clinical finding in patients with metastatic adenocarcinoma. This is a case report of a 69-year-old man, who presented with a cutaneous element by his umbilicus at his GP. He was referred to a dermatologist, then a plastic surgeon.
View Article and Find Full Text PDFRadiation Therapy for Sister Mary Joseph's Nodule: A Review.
Adv Radiat Oncol
February 2024
Department of Surgery, Misugikai Sato Hospital, Hirakata, Osaka, Japan.
Article Synopsis
- Umbilical metastasis, or Sister Mary Joseph's nodule (SMJN), indicates advanced cancer, primarily affecting the gastrointestinal tract in most cases, and often requires palliative care or radiation therapy as treatment options.
- A review of existing literature identified 275 articles and 255 case reports on SMJN, with findings highlighting the poor prognosis for patients, yet some can survive over two years.
- Radiation therapy has been less frequently documented, with only 7 reports detailing treatment, categorized into long/high-dose and short/low-dose protocols, reflecting the need for increased research on effective radiation strategies for SMJN.
Diffuse peritoneal carcinomatosis and Sister Mary Joseph nodule in ovarian carcinoma - exquisite demonstration of the peritoneal reflections on [18F]FDG PET/CT.
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Cobalt Medical Charity, Cheltenham, United Kingdom.
A case involving a 64-year-old woman with ovarian carcinoma on maintenance therapy who underwent 18-fluorodeoxyglucose positron emission tomography with computed tomography ([18F]FDG PET/CT) restaging due to rapid cancer antigen 125 (Ca-125) rise. This revealed recurrent disease within the pelvis and large volume, peritoneal carcinomatosis including an avid umbilical deposit, consistent with the rarely seen Sister Mary Joseph nodule (SMJN). This case elegantly demonstrates not only the anatomy of the peritoneal surfaces through avid disease deposition but also highlights the sensitive depiction of disease burden in peritoneal carcinomatosis, including the detection of rare manifestations such as SMJN.
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Radiation Oncology, Kyoto City Hospital, Kyoto, JPN.
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