Background: In this study, we present a case of Japanese spotted fever (JSF) caused by and use this case to investigate the process of diagnosing and reintegrating traceability of infectious diseases via metagenomic next-generation sequencing (mNGS).
Methods: From data relating to epidemiological history, clinical and laboratory examinations, and mNGS sequencing, a diagnosis of severe JSF was concluded.
Results: A detailed field epidemiological investigation discovered parasitic from a host animal (dog) in the domicile of the patient, within which was detected, along with a diverse array of other potentially pathogenic microorganisms that could cause other infectious diseases.
Conclusion: The mNGS provided an efficient method to diagnose JSF infection. This methodology could also be applied to field epidemiological investigations to establish the traceability of infectious diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10912839 | PMC |
| http://dx.doi.org/10.1016/j.imj.2024.100094 | DOI Listing |
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