It is known that the Metronome Response Task (MRT)-one of the most used mind-wandering sampling paradigms, struggles to differentiate between spontaneous mind-wandering (wherein one's attention is uncontrollably shifted away from the task at hand) and deliberate mind-wandering (wherein one's attention is purposefully shifted away). Thus, we endeavoured to design and test a new mind-wandering measure, called the In Sync Task (IST), that can achieve such differentiation more readily. Unlike the MRT, which involves having participants click in sync (using a mouse) with rhythmically presented, auditory monotones, the IST requires participants to (1) click in sync with tone triplets that increase incrementally in loudness and (2) modulate their clicking force to the presented tone's loudness. Here, we measured (1) participants' variabilities in their rhythmic response times (as is the MRT) and (2) their consistency in appropriately modulating their clicking force. Across two separate samples of university students (n = 119 and n = 121) collected between June 2022 to February 2023, we showed performance differences between the mind-wandering subtypes. Specifically, participants were better able to modulate their clicking force during epochs of spontaneous, compared with deliberate, mind-wandering, whereas the MRT was unable to differentiate between these conditions. In sum, we show that there appear to be greater costs to performance when one deliberately mind-wanders, as opposed to spontaneously mind-wandering.
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http://dx.doi.org/10.3758/s13414-024-02868-9 | DOI Listing |
Nucleic Acids Res
January 2025
School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland.
Copper compounds with artificial metallo-nuclease (AMN) activity are mechanistically unique compared to established metallodrugs. Here, we describe the development of a new dinuclear copper AMN, Cu2-BPL-C6 (BPL-C6 = bis-1,10-phenanthroline-carbon-6), prepared using click chemistry that demonstrates site-specific DNA recognition with low micromolar cleavage activity. The BPL-C6 ligand was designed to force two redox-active copper centres-central for enhancing AMN activity-to bind DNA, via two phenanthroline ligands separated by an aliphatic linker.
View Article and Find Full Text PDFGels
November 2024
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
This study presents the development of thiol-maleimide/thiol-thiol double self-crosslinking hyaluronic acid-based (HA) hydrogels for use as dermal fillers. Hyaluronic acid with varying degrees of maleimide substitution (10%, 20%, and 30%) was synthesized and characterized, and HA hydrogels were fabricated using two molecular weights of four-arm polyethylene glycol (PEG10K/20K)-thiol as crosslinkers. The six resulting HA hydrogels demonstrated solid-like behavior with distinct physical and rheological properties.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Technical University of MunichTUM School of Natural Sciences, Department of Chemistry, WACKER-Chair of Macromolecular Chemistry, Lichtenbergstraße 485748 Garching, Germany.
Langmuir
December 2024
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.
Biofouling can cause severe infections, device malfunctions, and failures in diagnostics and therapeutics. Proteins such as bovine serum albumin (BSA) have recently been used as coatings to resist biofouling because they combine surface anchoring and antifouling properties. However, their antifouling effectiveness will significantly deteriorate in complex biofluids with high salinity, limiting their practical applications.
View Article and Find Full Text PDFJ Am Chem Soc
November 2024
Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.
Stereoselective alkene 1,2-difunctionalization is a privileged strategy to access three-dimensional C(sp)-rich chiral molecules from readily available "flat" carbon feedstocks. State-of-the-art approaches exploit chiral transition metal-catalysts to enable high levels of regio- and stereocontrol. However, this is often achieved at the expense of a limited alkene scope and reduced generality.
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