Sneaky tactics: Ingenious immune evasion mechanisms of .

Virulence

Institute of Pathogenic Biology, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical College, University of South China, ChenZhou, Hengyang, China.

Published: December 2024

Gram-negative species are facultative intracellular bacteria that can survive in the harsh intracellular milieu of host cells. They have evolved strategies to evade detection and degradation by the host immune system, which ensures their proliferation in the host. Following infection, alters the initial immunogenic surface-exposed proteins to evade immune recognition via antigen or phase variation. The diverse lipopolysaccharide structures of certain species allow them to escape recognition by the host pattern recognition receptors. Additionally, the survival of mature erythrocytes and their resistance to lysosomal fusion further complicate the immune clearance of this species. Certain species also evade immune attacks by producing biofilms and anti-inflammatory cytokines and decreasing endothelial cell apoptosis. Overall, these factors create a challenging landscape for the host immune system to rapidly and effectively eradicate the species, thereby facilitating the persistence of infections and creating a substantial obstacle for therapeutic interventions. This review focuses on the effects of three human-specific species, particularly their mechanisms of host invasion and immune escape, to gain new perspectives in the development of effective diagnostic tools, prophylactic measures, and treatment options for infections.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936683PMC
http://dx.doi.org/10.1080/21505594.2024.2322961DOI Listing

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