AI Article Synopsis
- Obesity is a significant health issue that not only increases the risk of developing asthma but also worsens lung function and inflammation, complicating asthma treatment.
- Many patients with obesity-related asthma do not respond well to standard asthma treatments, highlighting the need for better understanding and new treatment options.
- Recent research is exploring different mechanisms behind obesity-related asthma and investigating new therapies, including biologics and antiobesity drugs, to improve patient outcomes.
Article Abstract
Purpose Of Review: Obesity is a growing global health threat that significantly contributes to the burden of asthma by increasing the risk of developing asthma and exerting a distinct effect on lung function and inflammation. The treatment of obesity-related asthma is hindered by a poor response to standard asthma treatments, leading to worse asthma control. Weight loss strategies have a significant effect on asthma symptoms but are not feasible for a large proportion of patients, underscoring the need for a better understanding of the pathophysiology and the development of additional treatment options.
Recent Findings: Recent literature focusing on pathophysiology particularly delved into nontype 2 inflammatory mechanisms, associations with the metabolic syndrome and small airway impairment. Additionally, several new treatment options are currently investigated, including biologics, weight reduction interventions, and novel antiobesity drugs.
Summary: Obesity-related asthma is a highly prevalent asthma phenotype for which weight loss strategies currently stand as the most specific treatment. Furthermore, novel pharmacological interventions aiming at metabolic processes are on the way.
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| http://dx.doi.org/10.1097/MCP.0000000000001073 | DOI Listing |
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