AI Article Synopsis
- The study highlights the role of interleukin-15 (IL-15), gluten, and the HLA-DQ8 gene in promoting tissue damage in coeliac disease, a condition where the immune system reacts negatively to gluten.
- It suggests that IL-15 enhances gluten's harmful effects on intestinal cells, resulting in inflammation and destruction of the gut lining.
- The findings provide insights into potential therapeutic targets for managing coeliac disease by blocking IL-15 or the immune response triggered by gluten.
Article Abstract
Commentary on: Abadie V et al. IL‐15, gluten and HLA‐DQ8 drive tissue destruction in coeliac disease. Nature. 2020; 578: 600‐604
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| http://dx.doi.org/10.1111/sji.13351 | DOI Listing |
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