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Stress regulatory hormones and cancer: the contribution of epinephrine and cancer therapeutic value of beta blockers.
Endocrine
January 2025
Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
The word "cancer" evokes myriad emotions, ranging from fear and despair to hope and determination. Cancer is aptly defined as a complex and multifaceted group of diseases that has unapologetically led to the loss of countless lives and affected innumerable families across the globe. The battle with cancer is not only a physical battle, but also an emotional, as well as a psychological skirmish for patients and for their loved ones.
View Article and Find Full Text PDFBacteria as Precision Tools for Cancer Therapy.
Microb Biotechnol
January 2025
Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain.
The discovery at the end of the 20th century of genes that induce cell death revolutionised the biocontaintment of genetically manipulated bacteria for environmental or agricultural applications. These bacterial 'killer' genes were then assayed for their potential to target and control malignant cells in human cancers. The identification of the bacteriomes in different human organs and tissues, coupled with the observation that bacteria tend to accumulate near tumours, has opened new avenues for anti-cancer strategies.
View Article and Find Full Text PDFIncidental venous thrombosis in oncology in a sub-Saharan tertiary hospital.
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Medical Oncology, General Hospital, PO Box 5408, Yaoundé, Cameroon.
The relationship between cancer and thrombosis was initially highlighted in the 19th century. Vascular complications in oncology can be arterial or venous thrombosis, and incidental pulmonary embolism is a growing challenge. We aimed to describe the frequency and clinical characteristics of cancer patients with incidental venous thromboembolism (iVTE).
View Article and Find Full Text PDFNew alternative colorectal anastomotic devices: A systematic review and meta-analysis.
Am J Surg
February 2025
Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA.
Article Synopsis
- Colorectal anastomotic devices have been used for almost 100 years, with stapled methods being most common, despite a significant leak risk of up to 20%.
- A systematic review and meta-analysis explored newer anastomotic devices, analyzing 18 studies from the last decade, which included 955 anastomoses and focused on non-stapled methods.
- The findings indicated a pooled complication rate of 9.7% for human studies, but new compression mechanisms showed a much lower leak rate of 3.3%, suggesting that these novel technologies could improve surgical outcomes.
Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer.
Gut
December 2024
Department of Surgery, University of South Florida Health, Tampa, Florida, USA
Background: Over a century ago, Virchow proposed that cancer represents a chronically inflamed, poorly healing wound. Normal wound healing is represented by a transitory phase of inflammation, followed by a pro-resolution phase, with prostaglandin (PGE2/PGD2)-induced 'lipid class switching' producing inflammation-quenching lipoxins (LXA4, LXB4).
Objective: We explored if lipid dysregulation in colorectal cancers (CRCs) is driven by a failure to resolve inflammation.
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