The investigation of hawthorn () plant's inhibition effect on angiotensin converting enzyme and studies.

Hawthorn plant is used among people due to its cardiovascular, anti-inflammatory, and antihistamine properties. But no scientific study has been done about (Mill.) M.Bieb. The presented study was planned to determine the effects of ethanol and n-hexane extracts of leaves on human plasma ACE enzyme. In the study, the effect of plant extracts on ACE was studied by the spectrophotometric method. The chemical composition of the plant extracts was determined by HPLC-DAD analyses. In addition, molecular doking and ADME prediction studies were carried out. As a result, the obtained data showed that could have an important place in the pharmaceutical industry and drug discovery studies, as it supports the traditional use of as hypotensive. The results of the molecular docking studies revealed that the interactions of the selected compounds with the human ACE enzyme caused inhibition.