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http://dx.doi.org/10.1016/j.bjao.2024.100265 | DOI Listing |
Physiol Plant
December 2024
Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.
As an important source of pollution in the papermaking process, the presence of lignin in poplar can seriously affect the quality and process of pulping. During lignin synthesis, Caffeoyl-CoA-O methyltransferase (CCoAOMT), as a specialized catalytic transferase, can effectively regulate the methylation of caffeoyl-coenzyme A (CCoA) to feruloyl-coenzyme A. Targeting CCoAOMT, this study investigated the substrate recognition mechanism and the possible reaction mechanism, the key residues of lignin binding were mutated and the lignin content was validated by deep convolutional neural-network model based on genome-wide prediction (DCNGP).
View Article and Find Full Text PDFFront Artif Intell
December 2024
School of Industrial Engineering and Management, Oklahoma State University, Stillwater, OK, United States.
The ability to accurately predict the yields of different crop genotypes in response to weather variability is crucial for developing climate resilient crop cultivars. Genotype-environment interactions introduce large variations in crop-climate responses, and are hard to factor in to breeding programs. Data-driven approaches, particularly those based on machine learning, can help guide breeding efforts by factoring in genotype-environment interactions when making yield predictions.
View Article and Find Full Text PDFBMC Bioinformatics
December 2024
College of Computer Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China.
As a heterogeneous disease, prostate cancer (PCa) exhibits diverse clinical and biological features, which pose significant challenges for early diagnosis and treatment. Metabolomics offers promising new approaches for early diagnosis, treatment, and prognosis of PCa. However, metabolomics data are characterized by high dimensionality, noise, variability, and small sample sizes, presenting substantial challenges for classification.
View Article and Find Full Text PDFDatabase (Oxford)
December 2024
School of Computing and Mathematical Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.
Visual analysis of peripheral blood smear slides using medical image analysis is required to diagnose red blood cell (RBC) morphological deformities caused by anemia. The absence of a complete anaemic RBC dataset has hindered the training and testing of deep convolutional neural networks (CNNs) for computer-aided analysis of RBC morphology. We introduce a benchmark RBC image dataset named Anemic RBC (AneRBC) to overcome this problem.
View Article and Find Full Text PDFCell Physiol Biochem
December 2024
Joint Institute for Nuclear Research, 141980 Dubna, Russiac.
Background/aims: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that severely affects cognitive functions and memory. Early detection is crucial for timely intervention and improved patient outcomes. However, traditional diagnostic tools, such as MRI and PET scans, are costly and less accessible.
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