AI Article Synopsis
- The review focuses on the unclear mechanisms of burning mouth syndrome (BMS) and the challenges in its management, with current treatments often providing inadequate pain relief.
- A comprehensive analysis of existing rodent models of BMS was conducted to identify gaps in understanding the condition's symptoms and causes.
- The findings suggest that merging different models could enhance research and lead to better experimental designs that consider the complexity of BMS, including sex- and hormone-related factors.
Article Abstract
Objectives: The underlying mechanisms of burning mouth syndrome (BMS) remain unclear leading to challenges and unsatisfactory management. Current treatments focus primarily on symptom relief, with few consistently achieving a 50% reduction in pain. This review aims to explore animal models of BMS to gain a better understanding of the underlying mechanisms and to discuss potential and existing knowledge gaps.
Methods: A comprehensive review of PubMed, Google Scholar, and Scopus was performed to assess advances and significant gaps of existing rodent models that mimic BMS-related symptoms.
Results: Rodent models of BMS involve reproduction of dry-tongue, chorda tympani transection, or overexpression of artemin protein. Existing preclinical models tend to highlight one specific etiopathogenesis and often overlook sex- and hormone-specific factors.
Conclusion: Combining aspects from various BMS models could prove beneficial in developing comprehensive experimental designs and outcomes encompassing the multifaceted nature of BMS.
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| http://dx.doi.org/10.1111/odi.14914 | DOI Listing |
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