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The effect of moisture during development on phenotypes of egg-laying reptiles: A systematic review and meta-analysis.
J Exp Biol
January 2025
Mount Allison University, Sackville, New Brunswick, Canada.
The embryonic environment is critical for the development of many ectothermic vertebrates, which makes them highly vulnerable to environmental change. Changes in temperature and moisture, in particular, are known to influence embryo survival and offspring phenotypes. While most papers concerning phenotypic development of terrestrial ectotherms focus on the role of temperature on eggs and embryos, the comparatively small number of studies on the effects of substrate moisture are well suited for quantitative analysis aimed at guiding future research.
View Article and Find Full Text PDFAlabama Embryo Ruling Threatened Access to In Vitro Fertilization Across the State and Possibly Nationwide.
Med Care
November 2024
Pennsylvania State University, Donald P. Bellisario College of Communications, University Park, PA.
Human placental stem cell-based therapies for prevention of abdominal adhesions: A prospective randomized preclinical trial.
J Trauma Acute Care Surg
January 2025
From the Department of Surgery (S.P.C.), Institute for Regenerative Medicine (S.P.C., P.K.C., J.W.V., A.A.), and Division of Public Health Sciences, Department of Biostatistics and Data Science (D.M.K.), Wake Forest School of Medicine, Winston-Salem, North Carolina; and Department of Surgery (J.B.H.), University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
Background: Abdominal adhesions are networks of fibrotic tissues that form between organs postoperatively. Current prophylactic strategies do not reproducibly prevent adhesive small bowel obstruction across the entire abdomen. Human placental-derived stem cells produce an anti-inflammatory secretome that has been applied to multiple fibrosing diseases.
View Article and Find Full Text PDFEmbryotoxicity of statins and other prescribed drugs with reported off-target effects on cholesterol biosynthesis.
Reprod Toxicol
December 2024
Department of Biological Sciences, Alabama State University, Montgomery, AL, United States; Center For NanoBiotechnology Research, Alabama State University, Montgomery, AL, United States. Electronic address:
Cholesterol plays pivotal cellular functions ranging from maintaining membrane fluidity to regulating cell-cell signaling. High cholesterol causes cardiovascular diseases, low cholesterol is linked to neuropsychiatric disorders, and inborn errors of cholesterol synthesis cause multisystem malformation syndromes. Statins lower cholesterol levels by inhibiting the first, rate-limiting reaction of the cholesterol biosynthesis pathway catalyzed by hydroxymethyl-glutaryl-Coenzyme A reductase (HMGCR).
View Article and Find Full Text PDFPlacental extracellular vesicles from women with severe preeclampsia alter calcium homeostasis in cardiomyocytes: an ex vivo study.
Am J Physiol Cell Physiol
January 2025
Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Women with severe preeclampsia (sPE) exhibit a heightened risk of postpartum cardiovascular disease compared with those with normotensive pregnancies (NTP). Although placental extracellular vesicles (EVs) play a crucial role in feto-maternal communication, their impact on cardiomyocytes, particularly in the context of sPE, remains unclear. This study investigated the effect of sPE-associated placental EVs (sPE-Plex EVs) on cardiomyocyte calcium dynamics.
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