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New approaches for understanding the potential role of microbes in Alzheimer's disease. | LitMetric

AI Article Synopsis

  • Alzheimer's disease is a complicated illness that develops over many years and is influenced by both our genes and the environment around us.
  • Scientists are exploring how germs might be linked to Alzheimer's, especially after new evidence from research related to COVID-19 and vaccines.
  • A recent online meeting brought experts together to discuss how microbes could affect Alzheimer's, focusing on questions like how they might cause harmful changes in the brain.

Article Abstract

Alzheimer's disease (AD) involves a complex pathological process that evolves over years, and its etiology is understood as a classic example of gene-environment interaction. The notion that exposure to microbial organisms may play some role in AD pathology has been proposed and debated for decades. New evidence from model organisms and -omic studies, as well as epidemiological data from the recent COVID-19 pandemic and widespread use of vaccines, offers new insights into the "germ hypothesis" of AD. To review new evidence and identify key research questions, the Duke/University of North Carolina (Duke/UNC) Alzheimer's Disease Research Center hosted a virtual symposium and workshop: "New Approaches for Understanding the Potential Role of Microbes in Alzheimer's disease." Discussion centered around the antimicrobial protection hypothesis of amyloid accumulation, and other mechanisms by which microbes could influence AD pathology including immune cell activation, changes in blood-brain barrier, or direct neurotoxicity. This summary of proceedings reviews the content presented in the symposium and provides a summary of major topics and key questions discussed in the workshop.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906156PMC
http://dx.doi.org/10.1016/j.bbih.2024.100743DOI Listing

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