Objectives: To evaluate the effects of a cell-free supernatant from (CFSM) on performance and diarrhearelated parameters and the presence of F4+ enterotoxigenic (ETEC) in piglets during post-weaning, and to evaluate the effect of the CFSM on gene expression in an F4+.
Animals And Procedure: In 3 trials with 90 piglets per trial, pigs were assigned to receive a placebo or 1 of 2 CFSM treatments and observed for diarrhea and performance. Fecal swabs were taken to determine the presence of ETEC. Quantitative RT-PCR was used to assess gene expression in 21259 after treatment with CFSM at 50 mg/mL.
Results: The CFSM administered for 14 d at a dose of 24 mg/kg BW (2X) reduced diarrhea-related parameters compared to the placebo. Quantitative RT-PCR showed that, in 21259 treated with CFSM at 50 mg/mL, expression of the gene was significantly repressed ( < 0.0001) relative to that in the untreated control.
Conclusion: The evaluated CFSM reduced the frequency and prevalence of diarrhea in a field situation. The treatment had an inhibitory effect on the expression of the gene in F4+ 21259.
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