AI Article Synopsis
- Allogeneic hematopoietic stem cell transplants (allo-HSCT) come with significant benefits but also carry risks like graft-versus-host disease (GVHD) during preconditioning and after the procedure.* -
- Effective risk management and early detection of GVHD rely on clinical features, highlighting the need for tools that can identify and manage patients proactively.* -
- This review focuses on the promise of proteomics-based biomarkers from non-invasive samples to improve diagnosis and treatment strategies for acute and chronic GVHD in patients undergoing allo-HSCT.*
Article Abstract
Despite the numerous advantages of allogeneic hematopoietic stem cell transplants (allo-HSCT), there exists a notable association with risks, particularly during the preconditioning period and predominantly post-intervention, exemplified by the occurrence of graft-versus-host disease (GVHD). Risk stratification prior to symptom manifestation, along with precise diagnosis and prognosis, relies heavily on clinical features. A critical imperative is the development of tools capable of early identification and effective management of patients undergoing allo-HSCT. A promising avenue in this pursuit is the utilization of proteomics-based biomarkers obtained from non-invasive biospecimens. This review comprehensively outlines the application of proteomics and proteomics-based biomarkers in GVHD patients. It delves into both single protein markers and protein panels, offering insights into their relevance in acute and chronic GVHD. Furthermore, the review provides a detailed examination of the site-specific involvement of GVHD. In summary, this article explores the potential of proteomics as a tool for timely and accurate intervention in the context of GVHD following allo-HSCT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904603 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1327035 | DOI Listing |
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