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Accelerated onset of diabetes in non-obese diabetic mice fed a refined high-fat diet. | LitMetric

AI Article Synopsis

  • This study examined how refined versus unrefined diets impact the onset and progression of high blood sugar (hyperglycaemia) in non-obese diabetic (NOD) mice, specifically looking at the effects on glucose tolerance and other health markers.
  • Female NOD mice on unrefined diets showed similar hyperglycaemia rates compared to those on refined diets, but those on a high-fat refined diet experienced faster onset of glucose intolerance.
  • The findings suggest that diet type significantly affects disease progression and microbiome composition, highlighting the importance of using matched control diets in diabetes research.

Article Abstract

Aim: Type 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka 'chow') diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice.

Methods: Female NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group.

Results: NOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had an accelerated onset of hyperglycaemia compared to the matched low-fat diet. There was no change in food intake, energy expenditure, or physical activity within each respective dietary group. Microbiome changes were driven by diet type, with chow diets clustering similarly, while refined low- and high-fat bacterial diversity also grouped closely. In the defined dietary cohort, liver gene expression changes in high-fat-fed mice were consistent with a greater frequency of hyperglycaemia and impaired glucose tolerance.

Conclusion: Glucose intolerance is associated with an enhanced frequency of hyperglycaemia in female NOD mice fed a defined high-fat diet. Using an appropriate matched control diet is an essential experimental variable when studying changes in microbiome composition and diet as a modifier of disease risk.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078605PMC
http://dx.doi.org/10.1111/dom.15522DOI Listing

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