AI Article Synopsis

  • Bubbles vibrating due to ultrasound are used in medicine for purposes like drug delivery and breaking up clots.
  • The study focused on how ultrasound frequency and power influence the flow of liquid near the bubbles, measuring different speeds of liquid movement at various power levels.
  • Experimental observations and simulations showed that as bubbles changed shape, they created vortices in the surrounding liquid, which could lead to useful stress patterns for medical applications.

Article Abstract

Bubbles oscillating in the presence of ultrasound is commonly employed in biomedical applications for drug delivery, ultrasound enhanced thrombolysis, and the transport and manipulation of cells. This is possible because bubbles tend to interact with the ultrasound to undergo periodic shape changes known as shape-mode oscillation, concomitant with the generation of liquid agitation or streaming. This phenomenon is examined both experimentally and theoretically on a single bubble at a frequency of (45 ± 1) kHz. Effects of ultrasonic frequency and power on the flowfield were explored. Experiments revealed different trends in the development of liquid streaming velocities at different acoustic forcing conditions (5.53, 6.80 and 7.02 Vpp), with lowest (0.5 mm/s) and highest (1.1 mm/s) values of time-averaged mean streaming velocity occurring at 6.80 Vpp and 7.02 Vpp, respectively. Simulations captured the simultaneous evolution of bubble-shapes that helped create flow vortices in the liquid surrounding the bubble. These vortices collectively responsible in generating signature patterns in the liquid for a dominant shape-mode of the bubble, and could also generate localised shear stresses for practical application. The velocity and pressure profiles in the liquid around the bubble confirmed the connection of the applied and reflected soundwaves in driving this phenomenon.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639710PMC
http://dx.doi.org/10.1016/j.ultsonch.2024.106816DOI Listing

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