AI Article Synopsis
- * Suspected drug-induced acute interstitial nephritis led to the discontinuation of the α-glucosidase inhibitor miglitol, which he had started two weeks prior.
- * A renal biopsy confirmed acute interstitial nephritis and diabetic nephropathy, and after stopping miglitol, the patient's urinary β2MG levels returned to normal, suggesting that miglitol may impair kidney function in those with pre-existing renal issues.
Article Abstract
A 79-year-old male patient with type 2 diabetic nephropathy and hypertension was admitted to our hospital because of acute kidney injury with significantly elevated serum creatinine (8.12 mg/dL) and urinary β2-microglobulin (β2MG, 31,748 μg/L) levels. α-glucosidase inhibitor (α-GI) miglitol, started two weeks prior to presentation, was discontinued because drug-induced acute interstitial nephritis (AIN) was suspected. Renal biopsy revealed AIN and diabetic nephropathy. The drug-induced lymphocyte stimulation test for miglitol was also positive. After the discontinuation of miglitol, the urinary β2MG levels decreased to the normal range. This case raises the possibility that α-GI miglitol can worsen the renal function in patients with underlying renal dysfunction.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557205 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.3156-23 | DOI Listing |
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