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NF-κB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation.
Cell Biochem Funct
June 2024
Department of Pharmacology and Therapeutics, Faculty of Health Sciences, Busitema University, Mbale, Uganda.
Diabetes mellitus (DM) is a collection of metabolic disorder that is characterized by chronic hyperglycemia. Recent studies have demonstrated the crucial involvement of oxidative stress (OS) and inflammatory reactions in the development of DM. Curcumin (CUR), a natural compound derived from turmeric, exerts beneficial effects on diabetes mellitus through its interaction with the nuclear factor kappa B (NF-κB) pathway.
View Article and Find Full Text PDFVindicating the scientific status of emotions and other affective phenomena: A teleological approach to the rescue.
Neurosci Biobehav Rev
April 2024
KU Leuven-University of Leuven, Tiensestraat 102, Leuven 3000, Belgium. Electronic address:
Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potential.
Int J Mol Sci
December 2023
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Str. 1, 119334 Moscow, Russia.
Driven by the growing threat of cancer, many research efforts are directed at developing new chemotherapeutic agents, where the central role is played by transition metal complexes. The proper ligand design serves as a key factor to unlock the anticancer potential of a particular metal center. Following a recent trend, we have prepared unsymmetrical pincer ligands that combine benzothiazole and thiocarbamate donor groups.
View Article and Find Full Text PDFHow a Minimal Learning Agent can Infer the Existence of Unobserved Variables in a Complex Environment.
Minds Mach (Dordr)
December 2022
Institute for Theoretical Physics, University of Innsbruck, Technikerstraße 21A, Innsbruck, 6020 Austria.
According to a mainstream position in contemporary cognitive science and philosophy, the use of abstract compositional concepts is amongst the most characteristic indicators of meaningful deliberative thought in an organism or agent. In this article, we show how the ability to develop and utilise abstract conceptual structures can be achieved by a particular kind of learning agent. More specifically, we provide and motivate a concrete operational definition of what it means for these agents to be in possession of abstract concepts, before presenting an explicit example of a minimal architecture that supports this capability.
View Article and Find Full Text PDFInfluence of Pore Size in Benzoin Condensation of Furfural Using Heterogenized Benzimidazole Organocatalysts.
Chemistry
December 2022
School of Chemistry, University of Southampton, Highfield campus, Southampton, SO171BJ, UK.
A designed N-heterocyclic carbene (NHC) catalyst was covalently anchored on a range of mesoporous and hierarchical supports, to study the influence of pore size in the benzoin condensation of furfural. The structural and spectroscopic characteristics of the anchored catalysts were investigated, also with the help of molecular dynamics simulations, in order to rationalize the degree of stability and recyclability of the heterogenized organocatalysts. Quantitative yields (99 %) and complete recyclability were maintained after several cycles, vindicating the design rationale.
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