AI Article Synopsis
- The study aimed to investigate how genetic haplotypes linked to celiac disease (HLA-DQ2 and HLA-DQ8) relate to endometriosis in Brazilian women.
- A retrospective study included 434 women, assessing those with and without endometriosis for symptoms and specific genetic markers.
- Results showed that while endometriosis was correlated with more pain and infertility, no significant differences in HLA-DQ2 or HLA-DQ8 were found between the two groups, suggesting no link between these genetic markers and endometriosis.
Article Abstract
Objective: To evaluate the relationship between genetic haplotypes associated with celiac disease (Human Leucocyte Antigen [HLA] DQ2 and DQ8) with the diagnosis, clinical presentation, and location of endometriosis in Brazilian women.
Method: A retrospective cross-sectional study, was conducted in a Tertiary hospital.
Patients: Women aged 18-50 years who underwent HLA-DQ2 and HLA-DQ8 haplotype analysis.
Intervention: The patients were divided into endometriosis and control groups and evaluated for symptoms; endometriosis location, American Society for Reproductive Medicine (ASRM) stage, and the presence of anti-tissue transglutaminase IgA (anti-TgA), HLA-DQ2, and HLA-DQ8 markers.
Results: A total of 434 consecutive patients with (n = 315) and without (n = 119) endometriosis were included. Pain and infertility were more frequent in the endometriosis group than in the control group. The presence of HLA-DQ2, HLA-DQ8, and anti-TgA was similar between both groups. The presence of HLA-DQ2 and HLA-DQ8 markers did not differ based on age, pain symptoms, ASRM stage, or endometriosis location.
Conclusion: Although there are similarities in inflammatory markers and pathophysiology between celiac disease and endometriosis, this study found no significant associations in the presence of HLA-DQ2 or HLA-DQ8 haplotypes and endometriosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10914556 | PMC |
| http://dx.doi.org/10.1016/j.clinsp.2023.100317 | DOI Listing |
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