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PRKAA2 Promotes Tumor Growth and Inhibits Ferroptosis through SLC7A11/GSH/GPX4 Pathway in Non-Small Cell Lung Cancer.
Biotechnol Appl Biochem
December 2024
Department of Thoracic Surgery, Affiliated Sanming First Hospital of Fujian Medical University Sanming, Fujian, China.
Non-small cell lung cancer (NSCLC) is the most pervasive sort of lung cancer with deadly outcome. According to recent studies, a number of neoplastic disorders and ferroptosis are intimately connected. This study aims to identify the role of key ferroptosis-related gene (protein kinase AMP-activated catalytic subunit alpha 2, PRKAA2) and explore new directions for the diagnosis and treatment of NSCLC.
View Article and Find Full Text PDFA Call for Diversity: Underrepresented Minorities and Cardiothoracic Anesthesiology Professional Development.
J Cardiothorac Vasc Anesth
November 2024
Stanford Department of Anesthesiology, Perioperative and Pain Medicine, Stanford, CA.
The presence of underrepresented minorities (URMs) in cardiothoracic anesthesiology is underwhelming, and progress toward diversity has been slow at best. Despite decades of efforts, change seems hard to achieve. For example, it took more than 30 years for women to make up 50% of medical school matriculants.
View Article and Find Full Text PDFAccelerating Scientific Discovery with AI.
Keio J Med
December 2024
Co-Founder and CEO, Google DeepMind.
This lecture will explore Google DeepMind's groundbreaking AI research and its transformative impact on the trajectory of scientific progress. It traces the path from AlphaGo, which mastered the complex game of Go through self-learning and innovative problem-solving, to AlphaFold, which revolutionized the field of protein structure prediction. Then, looking ahead to further AI-led advancements in medicine, materials science, climate science, and more, this lecture emphasizes Google DeepMind's commitment to safety and responsibility while pursuing advances in AI that benefit humanity.
View Article and Find Full Text PDFMaintenance therapy after first-line platinum-based chemotherapy in gastroenteropancreatic neuroendocrine carcinomas: A literature review.
Cancer Treat Rev
November 2024
Upper Gastrointestinal and Endocrine Tumor Unit, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Neuroendocrine carcinomas are rare and aggressive malignancies, often diagnosed at advanced stages, leading to poor prognosis. Platinum-based chemotherapy is the standard first-line treatment for advanced neuroendocrine carcinomas; however after achieving response no consensus exists on maintenance therapies and the results are inconsistent. This review examines the role of maintenance therapy following response to first-line chemotherapy in gastroenteropancreatic neuroendocrine carcinomas.
View Article and Find Full Text PDFThin flap sulcus-deepening trochleoplasty in patellar instability yields good functional outcomes without progressive cartilage deterioration in the short-term follow-up-A retrospective single-surgeon cohort study.
Knee Surg Sports Traumatol Arthrosc
December 2024
Sporthopaedicum, Berlin, Germany.
Purpose: Sulcus-deepening trochleoplasty (TP) effectively treats patellofemoral (PF) instability (PFI) caused by high-grade trochlear dysplasia (TD), but current evidence is based on small case series. We hypothesised, that TP would result in significant functional improvements and a low re-dislocation rate but would not accelerate the progression of PF cartilage deterioration.
Methods: We retrospectively reviewed all TP cases performed by a single surgeon between 2015 and 2021.
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