AI Article Synopsis
- A 24-year-old woman in Hungary developed human orf disease after feeding infected lambs, presenting symptoms like skin lesions, low-grade fever, and swollen lymph nodes.
- Laboratory tests identified the orf virus from the Poxviridae family, specifically strain Baja/2023/HUN, which closely matches sheep-origin orf viruses.
- This case marks the first recorded instance of human orf virus infection in Hungary, highlighting the disease's zoonotic potential.
Article Abstract
Human orf disease (called ecthyma contagiosum or contagious/infectious pustular dermatitis in animals) was confirmed on the fingers of both hands of a 24-year-old female, after feeding diseased lambs with a nursing bottle in April 2023. In addition to skin symptoms, she had low-grade fever (37.6°C) and swollen lymph nodes in both axilla. The presence of orf virus (genus Parapoxvirus, family Poxviridae) was confirmed, and this strain, Baja/2023/HUN (OR372161-OR372163), was found to have > 98% nucleotide sequence identity to sheep-origin orf viruses in four tested genome regions (ORF011/B2L, ORF019, ORF020/VIR, and ORF056). This is the first report of a human case of infection with the neglected zoonotic orf virus in Hungary.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908620 | PMC |
| http://dx.doi.org/10.1007/s00705-024-06002-w | DOI Listing |
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