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Ocular surface and meibomian gland evaluation in euthyroid Graves' ophthalmopathy. | LitMetric

AI Article Synopsis

  • - The study focused on Euthyroid Graves' ophthalmology (EGO), examining its effects on ocular surface and meibomian gland health in 34 EGO patients compared to 34 healthy individuals.
  • - Results indicated that EGO patients had significant ocular surface issues, such as higher disease index scores and more severe meibomian gland dropout, leading to symptoms like corneal staining and eyelid irregularities.
  • - Despite almost 60% of EGO patients reporting dry eye symptoms, the study found no signs of aqueous deficiency, suggesting further investigation is needed to understand the underlying causes of dry eyes in this group.

Article Abstract

Purpose: Euthyroid Graves' ophthalmology (EGO) refers to the subgroup of thyroid eye disease patients with distinct clinical presentations. This study evaluated the ocular surface and meibomian gland changes in EGO patients.

Methods: A cross-sectional study was conducted at The Chinese University of Hong Kong including 34 EGO patients and 34 age-and sex- matched healthy controls. Outcome measures include anterior segment examination, keratographic and meibographic imaging.

Results: Between 34 EGO patients and 34 age and sex-matched healthy controls, EGO was associated with a higher ocular surface disease index (P < 0.01), higher severity of meibomian gland dropout (upper: P < 0.001, lower: P < 0.00001) and higher percentage of partial blinking (P = 0.0036). The worse affected eyes of the EGO patients were associated with corneal staining (P = 0.0019), eyelid telangiectasia (P = 0.0009), eyelid thickening (P = 0.0013), eyelid irregularity (P = 0.0054), meibomian gland plugging (P < 0.00001), expressibility (P < 0.00001), and meibum quality (P < 0.00001). When the two eyes of the same EGO patient were compared, the degree of meibomian gland dropout was higher among the worse affected eyes (upper: P < 0.00001, and lower: P < 0.00001). Tear meniscus height, lipid layer thickness, and noninvasive break-up time were comparable between the two eyes of EGO patients and also between EGO patients and healthy controls. TMH was positively correlated with the degree of exophthalmos (r = 0.383, P < 0.05).

Conclusion: EGO patients have more ocular surface complications and meibomian gland dropouts than healthy controls. Almost 60% of them had dry eye symptoms, but aqueous deficiency was not apparent. Further studies are warranted to clarify the mechanism of dry eye in EGO. (249 words).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908617PMC
http://dx.doi.org/10.1007/s10792-024-02919-yDOI Listing

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