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Perianal Paget Disease With an Enteric Phenotype and Associated In-Situ/Dysplastic Glandular Component: Report of a Potentially Novel Entity and Review of the Literature.
Int J Surg Pathol
December 2024
College of Medicine, Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Extramammary Paget disease is an uncommon cutaneous malignancy that primarily affects areas rich in apocrine glands. Here, we aim to present an 84-year-old woman with a distinctive perianal neoplastic process comprised of conventional Paget disease with an intertwined in-situ glandular component. Rare foci of glands embedded in pools of mucin were also identified in the most recent excision, consistent with mucinous adenocarcinoma.
View Article and Find Full Text PDFRecommended guidelines for screening for underlying malignancy in extramammary Paget's disease based on anatomic subtype.
J Am Acad Dermatol
October 2024
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
Article Synopsis
- Extramammary Paget's disease (EMPD) can be linked to underlying internal adenocarcinomas, with varying associations based on the EMPD subtype.
- A systematic literature review identified that perianal EMPD has a higher rate (25%) of associated adenocarcinomas compared to penoscrotal and vulvar types (6% each).
- The proposed screening algorithms suggest specific tests based on EMPD subtype, emphasizing thorough screening for high-risk perianal cases and more cost-effective approaches for lower-risk penoscrotal and vulvar cases.
Hematoporphyrine injection-based photodynamic therapy for Perianal Paget's disease: A case report.
Photodiagnosis Photodyn Ther
December 2024
Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:
Article Synopsis
- Paget's disease of the perianal skin (PPD) is a rare skin condition that can be caused by issues in the colon or develop on its own.
- Surgery is usually the main treatment for PPD, but it can sometimes cause problems and isn't always a good option for older patients or those with severe cases.
- An alternative treatment called HpD-PDT helped a 70-year-old man with this condition by getting rid of the lesions without harming his ability to use the bathroom or causing other side effects.
Simultaneous Occurrence of Two Ectopic Extramammary Paget Disease Lesions: A Case Report.
Cureus
August 2024
Plastic Surgery, Japanese Red Cross Kochi Hospital, Kochi, JPN.
Article Synopsis
- Paget disease of the breast is a type of cancer affecting the nipple skin, while extramammary Paget disease occurs in other skin areas like the pubis and perianal regions.
- A case study is presented about a Japanese woman in her 70s who had two ectopic extramammary Paget disease lesions on her chest and buttock, which were surgically removed.
- This case is notable as it marks only the third instance of multiple simultaneous ectopic extramammary Paget disease and highlights the diagnostic challenges due to its unusual locations.
Utility of special AT-rich sequence-binding protein 2 (SATB2) immunohistochemistry as a marker for secondary perianal paget disease.
Virchows Arch
December 2024
Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA.
Article Synopsis
- A panel-based immunohistochemistry approach was used to subtype perianal Paget disease (PPD) and investigate the effectiveness of SATB2 as a marker for secondary PPD.
- In a study of 15 PPD cases, 53% were identified as secondary PPD, revealing distinct staining patterns, where SATB2 and CDX2 markers were key in differentiation.
- The findings suggest that combining IHC panels with clinical and imaging data enhances classification accuracy for PPD, with SATB2 serving as a valuable tool alongside CDX2.
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