AI Article Synopsis
- Malaria is a significant global health concern due to high morbidity and mortality rates, exacerbated by drug-resistant Plasmodium parasites.
- Lycopene, a natural compound found in red fruits and vegetables, was studied for its antimalarial effects, especially when used in combination with chloroquine, against chloroquine-resistant malaria.
- The research showed that lycopene not only had strong antimalarial activity but also improved blood health in animals infected with malaria, suggesting its potential as a new treatment option for malaria, particularly in resource-limited settings.
Article Abstract
Malaria remains a major public health issue worldwide, with high rates of morbidity and mortality. The resistance of Plasmodium parasites to commonly used antimalarial drugs has necessitated the development of novel drugs and targets for malaria treatment. Lycopene is a natural compound present in tomatoes and other red fruits and vegetables. This study aimed to evaluate the antimalarial activity of lycopene and its co-administration with chloroquine against chloroquine-resistant malaria, as well as to assess its impact on hematological abnormalities associated with malaria infection. The experimental animals for this study were infected with 10 NK65 Plasmodium berghei-infected red blood cells via intraperitoneal injection. The animals were then treated with artemether-lumefantrine, chloroquine, and varying doses of lycopene. The study evaluated percentage parasitemia, mean survival time, and various hematological parameters, including red blood cell count, hematocrit, hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin, red blood cell distribution width - coefficient of variation, red blood cell distribution width - standard deviation, white blood cell count, granulocyte count, lymphocyte count, monocyte count, and procalcitonin level. The study revealed that lycopene demonstrated significant (p < 0.05) antimalarial activity and the ability to ameliorate hematological abnormalities associated with acute malaria infection. The findings of this study highlight the potential of lycopene as a novel antimalarial agent. The results of this study may contribute to the development of new drugs for malaria treatment, particularly in low- and middle-income countries.
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| http://dx.doi.org/10.1016/j.parint.2024.102873 | DOI Listing |
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