AI Article Synopsis
- The "ribbon" structure of connected Golgi stacks is typically thought to exist only in vertebrates, but this study suggests it might have originated earlier in animal evolution.
- Researchers found ribbon-like structures in various metazoans, indicating that this architectural feature predates vertebrates and may be linked to processes like embryogenesis.
- The study proposes that the evolution of specific proteins (GRASP) may have facilitated the formation of these Golgi ribbons, which could have important biological roles that are still not fully understood.
Article Abstract
The "ribbon," a structural arrangement in which Golgi stacks connect to each other, is considered to be restricted to vertebrate cells. Although ribbon disruption is linked to various human pathologies, its functional role in cellular processes remains unclear. In this study, we investigate the evolutionary origin of the Golgi ribbon. We observe a ribbon-like architecture in the cells of several metazoan taxa suggesting its early emergence in animal evolution predating the appearance of vertebrates. Supported by AlphaFold2 modeling, we propose that the evolution of Golgi reassembly and stacking protein (GRASP) binding by golgin tethers may have driven the joining of Golgi stacks resulting in the ribbon-like configuration. Additionally, we find that Golgi ribbon assembly is a shared developmental feature of deuterostomes, implying a role in embryogenesis. Overall, our study points to the functional significance of the Golgi ribbon beyond vertebrates and underscores the need for further investigations to unravel its elusive biological roles.
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| http://dx.doi.org/10.1016/j.celrep.2024.113791 | DOI Listing |
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