Background: are often responsible for urinary tract infection (UTI) in kidney transplant recipients. Among these, or producing extended-spectrum beta-lactamase (ESBL) are emerging. However, there are only scarce data on frequency and impact of ESBL-UTI on transplant outcomes.
Methods: We investigated frequency and impact of first-year UTI events with ESBL and/or in a prospective multicenter cohort consisting of 1,482 kidney transplants performed between 2012 and 2017, focusing only on 389 kidney transplants having at least one UTI with and/or . The cohort had a median follow-up of four years.
Results: In total, 139/825 (17%) first-year UTI events in 69/389 (18%) transplant recipients were caused by ESBL-producing strains. Both UTI phenotypes and proportion among all UTI events over time were not different compared with UTI caused by non-ESBL-producing strains. However, hospitalizations in UTI with ESBL-producing strains were more often observed (39% versus 26%, = 0.04). Transplant recipients with first-year UTI events with an ESBL-producing strain had more frequently recurrent UTI (33% versus 18%, = 0.02) but there was no significant difference in one-year kidney function as well as longer-term graft and patient survival between patients with and without ESBL-UTI.
Conclusion: First-year UTI events with ESBL-producing and/or are associated with a higher need for hospitalization but do neither impact allograft function nor allograft and patient survival.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10902035 | PMC |
| http://dx.doi.org/10.3389/fmed.2024.1329778 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunoprophylaxis with MV140 Is Effective in the Reduction of Urinary Tract Infections-A Prospective Real-Life Study.
Vaccines (Basel)
December 2024
Urology Department, Hospital de Santa Maria, 1649-028 Lisbon, Portugal.
Background/objectives: Urinary tract infections (UTI) represent a highly frequent and debilitating disease. Immunoactive prophylaxis, such as the polyvalent bacterial whole-cell-based sublingual vaccine MV140, have been developed to avoid antibiotic use. However, the effectiveness of this tool in the Portuguese population is still unknown.
View Article and Find Full Text PDFTherapeutic Efficacy of Re-Lin-Qing Granules in Treating Type 2 Diabetes Mellitus Complicated with Urinary Tract Infection: A Retrospective Study.
Arch Esp Urol
December 2024
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, Zhejiang, China.
Purpose: Urinary tract infections (UTIs) frequently occur in patients with type 2 diabetes mellitus (T2DM), presenting a complex pathogenesis that significantly impairs patient quality of life. Despite the availability of various clinical treatments, challenges remain regarding their efficacy and safety. Therefore, this retrospective study aimed to observe the therapeutic effects of Re-Lin-Qing granules in treating T2DM complicated by UTIs, aiming to provide more scientifically validated and effective treatment options for clinical practice.
View Article and Find Full Text PDFLong-term efficacy of Mirabegron-anticholinergic combination in paediatric neurogenic bladder.
J Pediatr Urol
January 2025
Department of Women and Children's Health, School of Life Course Sciences, Kings College London, London, UK; Children's Bladder Service, Evelina London Children's Hospital, Westminster Bridge Road, London, SE1 7EH, UK.
Introduction: The Mirabegron-anticholinergic (MAC) combination has proven effective as a step-up strategy in managing paediatric neurogenic bladder following anticholinergic medication and botulinum toxin (BTX) therapy. This study assesses the long-term efficacy of MAC in children with neurogenic bladder.
Patients And Methods: A retrospective chart review was conducted from 2015 to 2023, including consecutive paediatric patients receiving Mirabegron (25/50 mg) with an anticholinergic agent (solifenacin 16, tolterodine 7, oxybutynin 7, trospium 1).
Perioperative Opioid Use in Total Shoulder Arthroplasty Is Associated with Dose-Dependent Risk of Major Surgical and Medical Complications.
J Shoulder Elbow Surg
December 2024
Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA, USA. Electronic address:
Introduction: Higher perioperative opioid use has been associated with an increase in periprosthetic joint infection, thromboembolic complications, respiratory events, gastrointestinal complications, cost, and length of stay following hip and knee arthroplasty. Limited data exists regarding the relationship between the postoperative opioid dose and complication rates following primary total shoulder arthroplasty (TSA). The purpose of this study is to investigate the relationship between perioperative opioid consumption and postoperative complications following TSA.
View Article and Find Full Text PDFNon-steroidal anti-inflammatory drugs for treating symptomatic uncomplicated urinary tract infections in non-pregnant adult women.
Cochrane Database Syst Rev
December 2024
Department of Urology, Freeman Hospital, Newcastle upon Tyne, UK.
Background: Almost half of all women will have at least one symptomatic urinary tract infection (UTI) in their lifetime. Although usually self-remitting, 74% of women contacting a health professional are prescribed an antibiotic, and in rare instances, they may progress to more severe infections. Therefore, the standard of care for the treatment of symptomatic uncomplicated UTIs is oral antibiotic therapy, which aims to achieve symptom resolution and prevent the development of complications such as pyelonephritis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!