AI Article Synopsis
- The Tibetan antelope, well-adapted to harsh conditions on the Qinghai-Tibet Plateau, has had its genomic study limited due to previous scaffold assembly challenges and lack of comparative analyses with other Bovidae species.
- A refined genome was developed using linkage disequilibrium analysis from 15 new samples, resulting in a scaffold N50 of 3.2 Mbp, which is 1.15 times better than the old version, and identified a total of 50,750 genes, including 29,324 novel ones.
- The research uncovered 182 unique genomic rearrangements, enhancing the understanding of the Tibetan antelope's evolutionary adaptations, and successfully reconstructed its X-chromosome,
Article Abstract
The Tibetan antelope () is a remarkable mammal thriving in the extreme Qinghai-Tibet Plateau conditions. Despite the availability of its genome sequence, limitations in the scaffold-level assembly have hindered a comprehensive understanding of its genomics. Moreover, comparative analyses with other Bovidae species are lacking, along with insights into genome rearrangements in the Tibetan antelope. Addressing these gaps, we present a multifaceted approach by refining the Tibetan Antelope genome through linkage disequilibrium analysis with data from 15 newly sequenced samples. The scaffold N50 of the refined reference is 3.2 Mbp, surpassing the previous version by 1.15-fold. Our annotation analysis resulted in 50,750 genes, encompassing 29,324 novel genes not previously study. Comparative analyses reveal 182 unique rearrangements within the scaffolds, contributing to our understanding of evolutionary dynamics and species-specific adaptations. Furthermore, by conducting detailed genomic comparisons and reconstructing rearrangements, we have successfully pioneered the reconstruction of the X-chromosome in the Tibetan antelope. This effort enhances our comprehension of the genomic landscape of this species.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10902437 | PMC |
| http://dx.doi.org/10.3389/fgene.2024.1302554 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evolutionary Analysis of Hypoderma Pantholopsum in Tibetan Antelopes on the Qinghai-Tibetan Plateau.
Acta Parasitol
January 2025
Academy of Animal Sciences and Veterinary Medicine, Qinghai University, Xining, People's Republic of China.
Purpose: Hypoderma pantholopsum is a parasite that parasitizes Tibetan antelopes (Pantholops hodgsonii). This study aims was to reveal the genetic diversity within H. pantholopsum and contribute to the protection of Tibetan antelope.
View Article and Find Full Text PDFA high-quality chromosome-level reference genome assembly of Tibetan antelope (Pantholops hodgsonii).
Sci Data
November 2024
Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, 810008, Qinghai, China.
Tibetan antelope (Pantholops hodgsonii), a wild ruminant endemic to the Qinghai-Tibetan Plateau (QTP) in China, has evolved a series of genetic and physiological adaptation strategies to thrive in the harsh plateau environments. However, limited research on the genome of this species exists. Here, we established a high-quality chromosome-level reference genome assembly of the Tibetan antelope using PacBio HiFi, DNBSEQ, and Hi-C sequencing data.
View Article and Find Full Text PDFsp. nov. and sp. nov., isolated from soil and faeces of Tibetan antelope () on the Qinghai-Tibet Plateau.
Int J Syst Evol Microbiol
July 2024
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, PR China.
Article Synopsis
- - Two new bacterial strains, HM61/HM23 and S-34/S-58, were discovered from soil and Tibetan antelope feces in the Qinghai-Tibet Plateau, characterized as aerobic, Gram-positive, and non-motile short rods.
- - Phylogenetic analysis based on 16S rRNA and core genomic genes revealed that these strains belong to distinct species within the same genus, showing high sequence similarity to known strains THG T63 and MMS20-HV4-12.
- - The study's findings led to the proposal of two novel species, named sp. nov. (for HM61) and sp. nov. (for S-34), with detailed descriptions of their chemotaxonomic
Exploring the Molecular Characteristics and Role of PDGFB in Testis and Epididymis Development of Tibetan Sheep.
Vet Sci
June 2024
College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Platelet-derived growth factor B (PDGFB), as an important cellular growth factor, is widely involved in the regulation of cellular events such as cell growth, proliferation, and differentiation. Although important, the expression characteristics and biological functions in the mammalian reproductive system remain poorly understood. In this study, the PDGFB gene of Tibetan sheep was cloned by RT-PCR, and its molecular characteristics were analyzed.
View Article and Find Full Text PDFMulti-omics reveal the gut microbiota-mediated severe foraging environment adaption of small wild ruminants in the Three-River-Source National Park, China.
Integr Zool
May 2024
Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, China.
The Tibetan antelope (Pantholops hodgsonii), blue sheep (Pseudois nayaur), and Tibetan sheep (Ovis aries) are the dominant small ruminants in the Three-River-Source National Park (TRSNP). However, knowledge about the association between gut microbiota and host adaptability remains poorly understood. Herein, multi-omics sequencing approaches were employed to investigate the gut microbiota-mediated forage adaption in these ruminants.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!