Flavonoids have been reported to be vital in treating various chronic disorders. Luteolin (3',4',5,7-tetrahydroxyflavone) is a flavonoid present in a variety of plant sources such as celery, green pepper, olive oil, peppermint, thyme, rosemary, oregano, etc. It has been reported to have various pharmacological activities such as antioxidant, anti-inflammatory, anticancer, antidiabetic, anti-Alzheimer, antimicrobial, etc. Many scientific studies have been carried out on luteolin for its possible effects on diabetes and its associated complications. The present review focuses on the role of luteolin in diabetes mellitus and the associated complications. The antidiabetic impact of luteolin is linked with the increased expression of PPARγ and GLUT. Various in vitro and in vivo studies have been performed to explore the effects of luteolin on diabetic complications, and it has shown a significant impact in the management of the same.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0115733998285798240217084632 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extracts Exert Anti-Melanogenic Properties via the CREB/MAPK Pathway in B16F10 Cells.
Mar Drugs
November 2024
Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Republic of Korea.
, a salt-tolerant plant, has demonstrated antioxidant effects, the ability to prevent prostate enlargement, antifungal properties, and skin moisturizing benefits. This study aimed to explore the anti-melanogenic potential of the 70% ethanol extract of (TME) along with its ethyl acetate (TME-EA) and water (TME-A) fractions. TME (10-200 µg/mL), TME-EA (1-15 µg/mL), and TME-A (100-1000 µg/mL) were prepared and applied to B16F10 cells with or without α-MSH for 72 h.
View Article and Find Full Text PDFLuteolin-mediated phosphoproteomic changes in chicken splenic lymphocytes: Unraveling the detoxification mechanisms against ammonia-induced stress.
J Hazard Mater
December 2024
Department of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:
Long-term exposure to high ammonia concentrations could severely impact chicken health. On the other hand, luteolin has been shown to protect against ammonia poisoning. Although phosphorylation is critically involved in toxicity induction, the specific role of phosphorylated proteins in ammonia poisoning remains unclear.
View Article and Find Full Text PDFFractionating the Flavonoids in Flos and via Solvent Extraction Coupled with Automated Solid-Phase Extraction.
Foods
November 2024
School of Pharmacy, Hubei University of Science and Technology, Xianning 437100, China.
Due to the structural diversity of flavonoids in functional plant foods and the inherent limitations of existing techniques, it is important to develop a simple and green (environmentally friendly) method of extracting flavonoids from plant foods. In this study, a method involving solvent extraction followed by automated solid-phase extraction was developed for extracting flavonoids from flos (JYH) and (SYH), both of which are widely used functional plant-based foods in Asian countries. For the optimisation of the solvent extraction method, solvent concentration (0.
View Article and Find Full Text PDFThe role and mechanism of "eight famous herbals in Zhejiang" in cancer via network pharmacology and experimental validation.
Front Oncol
November 2024
School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Article Synopsis
- Recent studies suggest that certain ingredients from the herbal formula "Zhe-Ba-Wei" may have potential antitumor effects, but comprehensive research on its role in cancer is lacking.
- Researchers identified 17 active ingredients related to tumors and narrowed it down to four key components (ferulic acid, quercetin, rutin, luteolin) linked by 27 common gene targets.
- The study found that ferulic acid, luteolin, and quercetin can inhibit the growth of non-small cell lung cancer cells and reduce EGFR protein levels, highlighting Zhe-Ba-Wei's potential in cancer treatment and its future research opportunities.
Chromosome-level genome assembly of Iodes seguinii and its metabonomic implications for rheumatoid arthritis treatment.
Plant Genome
November 2024
School of Life Sciences, Jiangsu University, Zhenjiang, China.
Iodes seguinii is a woody vine known for its potential therapeutic applications in treating rheumatoid arthritis (RA) due to its rich bioactive components. Here, we achieved the first chromosome-level assembly of the nuclear genome of I. seguinii using PacBio HiFi and chromatin conformation capture (Hi-C) sequencing data.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!